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Search Result

Search Results for " pi3kγ inhibitor 7 "

11

Compounds

Cat No. Product Name Synonyms Targets
T79111 PI3Kγ inhibitor 7 PI3K
PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1]. It also exhibits varying inhibitory effects on other PI3K i...
T3981 Acacetin 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin Apoptosis , IAP , COX , Autophagy
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.
T3656 PKI-402 PI3K , mTOR
PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.
T6732 WYE-687 p38 MAPK , PI3K , Src , mTOR
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fol...
T12469 PI4KIIIbeta-IN-9 PI3K , PI4K
PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .
T1916 Apitolisib RG 7422,GNE 390,GDC-0980 Apoptosis , PI3K , mTOR
Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal ce...
T36083 DS-7423 PI3K , mTOR
DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser...
T62165 PI3Kγ inhibitor 4
PI3Kγ inhibitor 4 is a selective, potent, orally active PI3Kγ inhibitor (IC50: 40 nM). PI3Kγ inhibitor 4 is ~7-fold more selective for PI3Kγ than the α subtype, 43-fold more selective than the β subtype and 18-fold more ...
T72270 WYE-687 dihydrochloride
WYE-687 dihydrochloride is an ATP-competitive inhibitor of mTOR, demonstrating potent activity with an IC 50 value of 7 nM. It effectively suppresses the activation of both mTORC1 and mTORC2. Additionally, WYE-687 exhibi...
T79370 FD2056 PI3K
FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. Additionally, it exhibits inhibitory effects on CDK2-CyclinA2 and ...
T35488 (S)-PI3Kα-IN-4 (S)-PI3Kα-IN-4
(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the...
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